Infection Epidemiology and Microbiology
Infection Epidemiology and Microbiology
IEM
Medical Sciences
http://iem.modares.ac.ir
1
admin
2588-4107
2588-4115
10.61186/iem
en
jalali
1394
10
1
gregorian
2016
1
1
2
1
online
1
fulltext
en
Pseudomonas aeruginosa: A review of their Pathogenesis and Prevalence in Clinical Settings and the Environment
The genus <em>Pseudomonas</em> consists of more than 120 species that are ubiquitous in moist environments such as water and soil ecosystems and are pathogenic to animals and humans. Within the genus of <em>Pseudomonas</em>, <em>P. aeruginosa </em>is most frequently associated with human infections. The bacterium is regarded as an opportunistic pathogen, primarily causing nosocomial infections in immunocompromised patients. The existing knowledge regarding the pathogenesis of <em>P. aeruginosa</em> has mainly been obtained through studying clinical isolates; particularly those involved in causing chronic lung infection in cystic fibrosis patients. Nosocomial infections commonly associated with <em>P. aeruginosa</em> include ventilator-associated pneumonia, catheter-associated urinary tract infections, wound infections in severe burn patients and septicaemia with their pathogenesis shown to be multifactorial. The bacterium is also capable of producing a number of toxins via the type III secretion system, as well as secreting enzymes and proteins including elastase, phospholipase C and siderophores. However, <em>P. aeruginosa</em> is also a waterborne pathogen, commonly found in environmental waters as well as in other sources such as sewage treatment plants. The public health implication of these bacteria whilst in the environment has not been fully investigated. Here we review our present knowledge about the pathogenesis of <em>P. aeruginosa</em> in clinical settings and the environment.
Pseudomonas aeruginosa,Virulence factors,Pathogenesis
25
32
http://iem.modares.ac.ir/browse.php?a_code=A-10-1000-5994&slc_lang=en&sid=4
Klrissa
Streeter
Klrissa
Streeter
100319475328460060638
100319475328460060638
No
Genecology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia
Genecology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia
Mohammad
Katouli
Mohammad
Katouli
100319475328460060639
100319475328460060639
Yes
Genecology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia
Genecology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia