Tarbiat Modares University Infection Epidemiology and Microbiology 2588-4107 7 3 2021 07 01 Epidemiological and Clinical Characteristics of Inactive Carriers of Hepatitis B Virus: A Descriptive Cross-Sectional Study in Burkina Faso 237 244 1854 10.52547/iem.7.3.237 EN Eric Nagaonlé Somé Institut de Recherche en Sciences de la Santé (IRSS), Biomedical and public health department, Ouagadougou, Burkina Faso Alice Nanelin Guingané University Joseph Ki-Zerbo, UFR/SdS, gastro-enterology department-Zerbo, UFR/SdS, gastro-enterology department Issaka Zongo Institut de Recherche en Sciences de la Santé (IRSS), Biomedical and public health department, Ouagadougou, Burkina Faso Mahamado Lamine Ouédraogo University Joseph Ki-Zerbo, UFR/SdS, gastro-enterology department-Zerbo, UFR/SdS, gastro-enterology department Maxime Drabo Institut de Recherche en Sciences de la Santé (IRSS), Biomedical and public health department, Ouagadougou, Burkina Faso Roger Sombié University Joseph Ki-Zerbo, UFR/SdS, gastro-enterology department-Zerbo, UFR/SdS, gastro-enterology department Journal Article Backgrounds: This study aimed to describe the epidemiological and clinical characteristics of inactive HBV chronic carriers at the gastroenterology department of the university teaching hospital Yalgado Ouedraogo.<br> Materials & Methods: This descriptive cross-sectional study was conducted from January 1, 2007 to December 31, 2014 by employing a prospective data collection method. It was a census of all cases meeting the eligibility criteria. All patients with chronic viral hepatitis B (VHB) and ≥15 years of age and presenting the following signs were included in this study: positive result on hepatitis B surface antigen test for at least 6 months, normal levels of alanine amino-transferase for at least one year, positive anti-HBe antibodies, negative HBeAg, and viral DNA < 20,000 IU/mL.<br> Findings: The mean age of patients was 35 years, and the mean duration of HBsAg carriage was 6 years. The physical examination was normal in all participants. Ultrasound exam was normal in 150 (92.6%) participants and showed a fatty liver in 12 (7.4%) participants. Overall 4.4% of participants developed severe fibrosis, and no patient developed cirrhosis. The main indications for drug treatment included the existence of a family history of hepatocellular carcinoma (36.7%), the presence of active hepatitis (33.3%), and the progression of the fibrosis (30%).<br> Conclusion: This study confirms the importance of close follow up of HBV-infected patients to dramatically reduce the risk of developing complications such as cirrhosis or hepatocellular carcinoma. https://iem.modares.ac.ir/article_1854_49ad23d1ec9fa4bd8d77d02681df5cfa.pdf