Tarbiat Modares University Infection Epidemiology and Microbiology 2588-4107 9 1 2023 03 01 Thromboembolic Manifestations in Hospitalized COVID-19 Patients in India- A Single-Centre Retrospective Study 79 85 1916 10.52547/iem.9.1.79 EN Yoganathan Chidambaram Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India Clement Jenil Dhas Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India Nekkanti Abilash Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India Velammal Petchiappan Associate Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India Murali Alagesan Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India Journal Article 1970 01 01 Backgrounds: This study aimed to evaluate the incidence and clinical profile of thromboembolic disease in COVID-19 patients and analyze its association with D-dimer and Interleukin (IL)-6 levels. Materials & Methods: This was a retrospective, single-center study conducted by analyzing data obtained from the case records of COVID-19 confirmed patients with thromboembolic manifestations in India during January 2020 to February 2022. Patients with conditions such as malignancy, prothrombotic states, and autoimmune diseases were excluded from the analysis. D-dimer and IL-6 levels and thrombotic events were analyzed along with comorbid conditions like diabetes mellitus (DM), hypertension, and dyslipidemia. Chi-square tests were used to evaluate the association of various thrombotic manifestations with D-dimer and IL-6 levels. A p-value of ≤ .05 was considered statistically significant. Findings: The mean age of 88 COVID-19 confirmed cases with thrombotic manifestations was 61.01±15.23 years, and the majority (62.5%) of the cases were male. D-dimer and IL-6 levels were elevated in 78.41 and 80.68% of the cases, respectively. The predominant thrombotic manifestation was pulmonary thromboembolism (PTE) (48.86%), followed by acute coronary syndrome (ACS) (36.36%), cerebrovascular accident (CVA) (22.73%), etc. There was no significant association between various thrombotic manifestations and D-dimer and IL-6 levels. Conclusion: PTE was the predominant thromboembolic manifestation in COVID-19 patients in the current cohort. Elevated D-dimer and IL-6 levels though found in the majority of the patients were not associated with thrombotic events. However, early recognition and treatment could reduce morbidity in COVID-19 patients.

https://iem.modares.ac.ir/article_1916_65fc52ed8f88c81323a418ca94cec2ed.pdf