Tarbiat Modares University Infection Epidemiology and Microbiology 2588-4107 12 1 2026 02 01 Dengue virus infection and Skin Manifestations: A Systematic Review and Meta-Analysis 87 99 28718 10.66224/iem.12.1.87 EN Fatemeh Sameni Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 0000-0001-5762-1279 Mehrshad Ahmadi Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Mohammad Mohammadzadeh Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran 0000-0001-8526-4504 Seyed Mehdi Tabaie Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran Amir Bairami Department of Medical Parasitology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Maedeh Pourali Eshkalak Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Masoud Dadashi Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran Journal Article 2025 08 28 <strong>Background:</strong> Dengue virus infection is a severe systemic condition primarily transmitted by its main vector, Aedes aegypti. Skin rash may be the initial symptom in patients with dengue virus infection, which could be helpful for clinical diagnosis. This research aimed to evaluate the prevalence of skin manifestations associated with dengue virus infection worldwide. <br><strong>Materials & Methods:</strong> Electronic resources such as Scopus, Medline (via PubMed), and Web of Science were searched to identify studies focusing on skin manifestations in patients with dengue virus infection between 2000 and 2024. Statistical analysis was conducted using Stata software, and sources of heterogeneity were assessed using I2. <br><strong>Findings:</strong> A total of 24 papers (six prevalence studies and 18 case reports/case series) were included. A meta-analysis of prevalence studies revealed that skin manifestations were reported in patients with dengue virus infection in three countries (India, Pakistan, and France), with an overall prevalence of 63.2% (95% CI: 54.4-71.1) among 962 dengue virus infected patients. Analysis of case reports/case series showed that among 19 dengue virus infected cases, skin rash and thrombocytopenia were the most common skin manifestations and laboratory indications, respectively.<br><strong>Conclusion:</strong> Dengue virus infection could result in various dermal manifestations with distinct clinical symptoms and laboratory findings. These skin involvements may aid in the timely diagnosis of patients with dengue virus infection. https://iem.modares.ac.ir/article_28718_c022cf41a12658e227aeb252f734364d.pdf