Volume 7, Issue 2 (2021)
IEM 2021, 7(2): 161-172 |
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Jaafari A, Lekchiri S, Zahir H, Ellouali M, Badou A, Latrache H. A Cross-Immunity between SARS-CoV-2 and MERS-CoV: Interest in Anti-SARS-CoV-2 Serotherapy Development Using Dromedary Serum. IEM 2021; 7 (2) :161-172
URL: http://iem.modares.ac.ir/article-4-51209-en.html
URL: http://iem.modares.ac.ir/article-4-51209-en.html
Abdeslam Jaafari * 
1, Souad Lekchiri2 , Hafida Zahir2 , Mostafa Ellouali2 , Abdallah Badou , Hassane Latrache2
1, Souad Lekchiri2 , Hafida Zahir2 , Mostafa Ellouali2 , Abdallah Badou , Hassane Latrache2
1- 1. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: 523, BeniMellal, 23000, Morocco , abdeslamjaafari@gmail.com
2- 1. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: 523, BeniMellal, 23000, Morocco
2- 1. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: 523, BeniMellal, 23000, Morocco
Abstract: (1582 Views)
Backgrounds: A potential cross-immunity between SARS-CoV-2 and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-2 using dromedary camel anti MERS-CoV serum.
Materials & Methods: Epidemiological and 66 literature data, of which 35 have been published during 2015-2021, and findings were analysed.
Findings: According to the statistical data reported during COVID-19 pandemic, there are less cases and deaths associated with COVID-19 in countries known for dromedary breeding and the circulation of MERS-CoV (another betacoronavirus disease transmitted by dromedary camels) among humans and dromedaries. This observation and the similarity in genome and immunopathogenicity between SARS-CoV-2 and MERS-CoV, suggest that individuals who have been in contact with MERS-CoV infected dromedaries and/or consumed their products (milk, meat, urine) might have acquired an immunity protecting them against SARS-CoV-2. In addition to neutralizing antibodies, this immunity could also be due to complement proteins, chemokines, and especially antimicrobial peptides (AMP), known for their effect on enveloped viruses.
Conclusion: Most research has focused on vaccines as a solution to stop the pandemic, while serotherapy hasn’t significantly aroused the interest of researchers. This potential cross-immunity between SARS-CoV-2 and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-2 using dromedary camel anti MERS-CoV serum.
Materials & Methods: Epidemiological and 66 literature data, of which 35 have been published during 2015-2021, and findings were analysed.
Findings: According to the statistical data reported during COVID-19 pandemic, there are less cases and deaths associated with COVID-19 in countries known for dromedary breeding and the circulation of MERS-CoV (another betacoronavirus disease transmitted by dromedary camels) among humans and dromedaries. This observation and the similarity in genome and immunopathogenicity between SARS-CoV-2 and MERS-CoV, suggest that individuals who have been in contact with MERS-CoV infected dromedaries and/or consumed their products (milk, meat, urine) might have acquired an immunity protecting them against SARS-CoV-2. In addition to neutralizing antibodies, this immunity could also be due to complement proteins, chemokines, and especially antimicrobial peptides (AMP), known for their effect on enveloped viruses.
Conclusion: Most research has focused on vaccines as a solution to stop the pandemic, while serotherapy hasn’t significantly aroused the interest of researchers. This potential cross-immunity between SARS-CoV-2 and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-2 using dromedary camel anti MERS-CoV serum.
Article Type: Qualitative Research |
Subject:
Virology
Received: 2021/03/29 | Accepted: 2021/04/30 | Published: 2021/05/20
Received: 2021/03/29 | Accepted: 2021/04/30 | Published: 2021/05/20
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