Volume 9, Issue 1 (2023)
IEM 2023, 9(1): 0-0 |
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Chidambaram Y, Jenil Dhas C, Abilash N, Petchiappan V, Alagesan M. Thromboembolic manifestations in hospitalized COVID-19 patients in India- A single-centre retrospective study. IEM 2023; 9 (1)
URL: http://iem.modares.ac.ir/article-4-65604-en.html
URL: http://iem.modares.ac.ir/article-4-65604-en.html
Yoganathan Chidambaram *1, Clement Jenil Dhas2, Nekkanti Abilash2, Velammal Petchiappan3, Murali Alagesan4
1- Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India , yoganathancc@gmail.com
2- Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
3- Associate Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
4- Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
2- Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
3- Associate Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
4- Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
Abstract: (162 Views)
Aims: To evaluate the incidence and clinical profile of thromboembolic disease in COVID-19 patients and to analyze its association with levels of D-dimer and Interleukin (IL)-6.
Materials & Methods: This was a retrospective, single-centre study conducted analyzing the data obtained from the case records of COVID-19 confirmed patients with thromboembolic manifestations. Patients with conditions such as malignancy, prothrombotic states, and autoimmune diseases were excluded from the analyses. D-dimer and IL-6 levels, and thrombotic events along with presence of comorbid conditions like diabetes mellitus (DM), hypertension, and dyslipidemia were analyzed. Chi-square tests were used to evaluate the association of various thrombotic manifestations with levels of D-dimer and IL-6. p-value ≤0.05 was considered statistically significant.
Findings: The mean age of 88 COVID-19 confirmed cases with thrombotic manifestations was 61.01±15.23 years and the majority (62.5%) of the cases were males. D-dimer and IL-6 levels were elevated in 78.41% and 80.68% cases, respectively. The predominant thrombotic manifestation was pulmonary thromboembolism (PTE) which was observed in 48.86% cases, followed by acute coronary syndrome (ACS) (36.36%), cerebrovascular accident (CVA) (22.73%), etc. There was no significant association of various thrombotic manifestations with D-dimer and IL-6 levels.
Conclusion: PTE was the predominant thromboembolic manifestation in COVID-19 patients in the current cohort. Elevated D-dimer and IL-6 levels though found in majority of the patients were not associated with thrombotic events. However, early recognition and treatment could reduce morbidity in COVID-19 patients.
Materials & Methods: This was a retrospective, single-centre study conducted analyzing the data obtained from the case records of COVID-19 confirmed patients with thromboembolic manifestations. Patients with conditions such as malignancy, prothrombotic states, and autoimmune diseases were excluded from the analyses. D-dimer and IL-6 levels, and thrombotic events along with presence of comorbid conditions like diabetes mellitus (DM), hypertension, and dyslipidemia were analyzed. Chi-square tests were used to evaluate the association of various thrombotic manifestations with levels of D-dimer and IL-6. p-value ≤0.05 was considered statistically significant.
Findings: The mean age of 88 COVID-19 confirmed cases with thrombotic manifestations was 61.01±15.23 years and the majority (62.5%) of the cases were males. D-dimer and IL-6 levels were elevated in 78.41% and 80.68% cases, respectively. The predominant thrombotic manifestation was pulmonary thromboembolism (PTE) which was observed in 48.86% cases, followed by acute coronary syndrome (ACS) (36.36%), cerebrovascular accident (CVA) (22.73%), etc. There was no significant association of various thrombotic manifestations with D-dimer and IL-6 levels.
Conclusion: PTE was the predominant thromboembolic manifestation in COVID-19 patients in the current cohort. Elevated D-dimer and IL-6 levels though found in majority of the patients were not associated with thrombotic events. However, early recognition and treatment could reduce morbidity in COVID-19 patients.
Article Type: Original Research |
Subject:
Virology
Received: 2022/11/24 | Accepted: 2023/02/27 | Published: 2023/03/10
Received: 2022/11/24 | Accepted: 2023/02/27 | Published: 2023/03/10
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