Volume 10, Issue 3 (2024)
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Mohamadi A, Hashemi S J, Daie Ghazvini R, Rezaei S, Rafat Z, Ardi P. Detection of the In-Vitro Inhibitory Effects of Nitroglycerin on Candida albicans, Trichophyton rubrum, and Aspergillus flavus. IEM 2024; 10 (3)
URL: http://iem.modares.ac.ir/article-4-74218-en.html
URL: http://iem.modares.ac.ir/article-4-74218-en.html
Afsaneh Mohamadi1 
, Seyed Jamal Hashemi * 2, Roshanak Daie Ghazvini1 , Sassan Rezaei1 , Zahra Rafat3 , Pegah Ardi4
, Seyed Jamal Hashemi * 2, Roshanak Daie Ghazvini1 , Sassan Rezaei1 , Zahra Rafat3 , Pegah Ardi4
1- Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. ,sjhashemi@tums.ac.ir
3- Department of Medical Parasitology and Mycology, School of Medicine, Guilan University ofMedical Sciences, Rasht, Iran
4- Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. ,
3- Department of Medical Parasitology and Mycology, School of Medicine, Guilan University ofMedical Sciences, Rasht, Iran
4- Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abstract: (267 Views)
Backgrounds: The present investigation aimed to survey the in-vitro inhibitory effects of nitroglycerin against Candida albicans, Trichophyton rubrum, and Aspergillus flavus.
Materials & Methods: In the current investigation, 99 fungal isolates were gathered from patients referred to the Medical Mycology Laboratory of Tehran University of Medical Sciences. The disk diffusion method was done based on Clinical and Laboratory Standards Institute (CLSI) M44-S2 guidelines. Also, the microdilution method was performed base on CLSI guidelines for filamentous fungi (document M38-A2) and yeasts (document M27-A3).
Findings: In the disk diffusion method, all isolates of C. albicans (n=33, 100%) and A. flavus (n=33, 100%) showed sensitivity to nitroglycerin, whereas all isolates of T. rubrum (n=33, 100%) showed resistance to nitroglycerin. On the other hand, in the microdilution method, the minimum inhibitory concentration (MIC) of nitroglycerin against C. albicans and A. flavus isolates was 0.5 mg/mL, whereas the MIC of nitroglycerin against T. rubrum was 0.12 mg/mL.
The results showed that the MIC of nitroglycerin against dermatophytes was about one-quarter of its MIC against C. albicans and A. flavus, and this difference was statistically significant (p< .05).
Conclusion: Considering the potential and efficacy of nitroglycerin against yeasts and filamentous fungi (saprophytes and dermatophytes), complementary in-vivo and in-vitro studies should be done.
Materials & Methods: In the current investigation, 99 fungal isolates were gathered from patients referred to the Medical Mycology Laboratory of Tehran University of Medical Sciences. The disk diffusion method was done based on Clinical and Laboratory Standards Institute (CLSI) M44-S2 guidelines. Also, the microdilution method was performed base on CLSI guidelines for filamentous fungi (document M38-A2) and yeasts (document M27-A3).
Findings: In the disk diffusion method, all isolates of C. albicans (n=33, 100%) and A. flavus (n=33, 100%) showed sensitivity to nitroglycerin, whereas all isolates of T. rubrum (n=33, 100%) showed resistance to nitroglycerin. On the other hand, in the microdilution method, the minimum inhibitory concentration (MIC) of nitroglycerin against C. albicans and A. flavus isolates was 0.5 mg/mL, whereas the MIC of nitroglycerin against T. rubrum was 0.12 mg/mL.
The results showed that the MIC of nitroglycerin against dermatophytes was about one-quarter of its MIC against C. albicans and A. flavus, and this difference was statistically significant (p< .05).
Conclusion: Considering the potential and efficacy of nitroglycerin against yeasts and filamentous fungi (saprophytes and dermatophytes), complementary in-vivo and in-vitro studies should be done.
Keywords: Nitroglycerin, Minimum inhibitory concentrations, Candida albicans, Aspergillus flavus, Trichophyton rubrum
Article Type: Original Research |
Subject:
Mycology
Received: 2024/03/10 | Accepted: 2024/06/19 | Published: 2024/08/20
Received: 2024/03/10 | Accepted: 2024/06/19 | Published: 2024/08/20
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