Seroprevalence of HCV Infection among Health Care Workers in Two Teaching Hospitals, Tehran, Iran

Authors
1 Antimicrobial Resistance Research Center, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, IR Iran Infectious diseases department, Iran University of Medical Sciences, Tehran, IR Iran.
2 Internal medicine department, Iran University of Medical Sciences, Tehran, IR Iran.
3 Gastroenterologist, Internal medicine department, Iran University of Medical Sciences, Tehran, Iran.
4 Department of virology, Iran University of Medical Sciences, Tehran-Iran.
5 Pediatric infectious diseases research center, Infectious diseases department, Iran University of Medical Sciences, Tehran-Iran.
6 Forensic medicine department, Iran University of Medical Sciences, Tehran-Iran.
Abstract
Background: Health care workers (HCWs) are at the risk of the acquisition of occupational transmissible diseases. Controversial results have been reported about hepatitis C virus (HCV). The main objective of the recent study was to evaluate the seroprevalence of HCV and its relationship to the occupational history and exposure of HCWs in two teaching hospitals in Tehran-Iran.

Materials and Methods: A seroprevalence survey of HCV was conducted using serum samples obtained from 1400 HCWs in two teaching hospitals during 2012. The samples were screened by ELISA for the presence of anti-HCV antibodies.

Results: In none of the participants the HCV antibody was detected. Needle stick injury was significantly higher among nurses. Younger HCWs with a shorter professional life had more frequent needle stick injury (p<0.001).

Conclusion: The seroprevalence of HCV in HCWs was considerably lower than that reported in the general population, and needs to be evaluated on a larger scale.

Keywords


  1. wicker S, Jung J, Allwinn R, Gottschalk R, Rabenau HF. Prevalence and prevention of needle-stick injuries among health care workers in a German university hospital. Int Arch Occup Environ Health 2008; 81(3): 347-54.

  2. Pruss-Ustün A, Rapiti E, Hutin Y. Estimation of the global burden of disease attributable to contaminated sharps injuries among health-care workers. Am J Ind Med 2005; 48(6): 482-90.

  3. Kao JH, Chen DS. Transmission of hepatitis C virus in Asia: past and present perspectives. J Gastroenterol Hepatol 2000; 15Suppl: E91-6. Review.

  4. Merat S, Rezvan H, Nouraie M, Jafari E, Abolghasemi H, Radmard AR, et al. Seroprevalence of hepatitis C virus: the first population-based study from Iran. Int J Infect Dis 2010; 14 Supp 3: e113-6.

  5. Ansari-Moghaddam A, Ostovaneh MR, Sharifi Mood B, Sanei-Moghaddam E, Modabbernia A, Poustchi H. Seroprevalence of hepatitis B surface antigen and anti hepatitis C antibody in Zahedan city, Iran: a population-based study. Hepat Mon 2012; 12(9): e 6618.

  6. Makhlough A, Jamshidi M, Mahdavi MR. Hepatitis C prevalence studied by polymerase chain reaction and serological methods in haemodialysis patients in Mazandaran, Iran. Singapore Med J 2008;49(11): 921-3.

  7. Alavian SM, Adibi P, Zali MR. Hepatitis C virus in Iran: epidemiology of an emerging infection. Arch Iran Med 2005; 8(2): 84-90.

  8. Imani R, Karimi A, Rouzbahani R, Rouzbahani A. Seroprevalence of HBV, HCV, and HIV infection among intravenous drug users in Shahr-e-Kord, Islamic Republic of Iran. East Mediterr Health J 2008; 14(5): 1136-41.

  9. Kheirandish P, SeyedAlinaghi S, Jahani M, Shirzad H, Seyed Ahmadian M, Majidi A, et al. Prevalence and correlates of hepatitis C infection among male injection drug users in detention, Tehran, Iran. J Urban Health 2009; 86(6): 902-8.

  10. Tamaddoni A, Mohammadzadeh I, Ziaei O. Seroprevalnce of HCV antibody among patients with beta-thalassemia major in Amirkola Thalassemia center, Iran. Iran J Allergy Asthma Immunol 2007; 6(1): 41.

  11. Thorburn D, Dundas D, McCruden EA, Cameron SO, Goldberg DJ, Symington IS, et al. A study of hepatitis C prevalence in healthcare workers in the West of Scotland. Gut 2001;48(1): 116-20.

  12. Catalani C, Biggeri A, Gottard A, Benvenuti M, Frati E, Cecchini C. Prevalence of HCV infection among health care workers in a hospital in central Italy. Eur J Epidemiol 2004; 19(1): 73-7.

  13. Jindal N, Jindal M, Jilani N, Kar P. Seroprevalence of hepatitis C virus(HCV) in health care workers of a tertiary care centre in New Delhi. Indian J Med Res 2006; 123(2): 179-80.

  14. Aziz S, Memon A, Tily HI, Rasheed K, Jehangir K, Quraishy MS. Prevalence of HIV, hepatitis B and C amongst health workers of Civil Hospital Karachi. J Pak Med Assoc 2006; 56(1 supp 1): S48-50.

  15. Tarantola A, Abiteboul D, Rachline A. Infection risks following accidental exposure to blood or body fluids in health care workers: a review of pathogens transmitted in published cases. Am J Infect Control 2006; 34(6): 367-75.

  16. Shoaei P, Lotfi N, Hassannejad R, Yaran M, Ataei B, Kassaian N, et al. Seroprevalence of Hepatitis C infection among health care workers in Isfahan, Iran. Int J Prev Med 2012; 3(Suppl 1): S146-9.

  17. Kuruuzum Z, Yapar N, Avkan-Oguz V, Aslan H, Ozbek OA, Cakir N, et al. Risk of infection in health care workers following occupational exposure to a noninfectious or unknown source. Am J Infect Control 2008; 36(10): e27-31.

  18. Lodi G, Porter SR, Teo CG, Scully C. Prevalence of HCV infection in health care workers of a UK dental hospital. Br Dent J 1997; 183(9): 329-32.

  19. Deuffic-Burban S, Delarocque-Astagneau E, Abiteboul D, Bouvet E, Yazdanpanah Y. Blood-borne viruses in health care workers: prevention and management. J Clin Virol 2011; 52(1): 4-10.

  20. .Karstaedt AS, Pantanowitz L. Occupational exposure of interns to blood in an area of high HIV seroprevalence. S Afr Med J 2001; 91(1): 57-61.

  21. Nail A, Eltiganni S, Imam A. Seroprevalence of hepatitis B and C among health care workers in Omdurman, Sudan. Sudan JMS 2008; 3(3): 201-3.

  22. Santos-López G, Sosa-Jurado F, Vallejo-Ruiz V, Meléndez-Mena D, Reyes-Leyva J. Prevalence of hepatitis C virus in the Mexican population: a systematic review. J Infect 2008; 56(4): 281-90.

  23. Hadadi A, Afhami S, Karbakhsh M, Esmailpour N. Occcupational exposure to body fluids among healthcare workers: a report from Iran. Sigapore Med J 2008; 49(6): 492- 6.

  24. Blazquez RM, Moreno S, Menasalvas A, Guerrero C, Novoa A, Segovia M. Occupational exposures to blood-borne pathogens in health care workers. Enferm Infect Microbiol Clin 2001; 19(4): 156-60.

  25. Tarantola A, Golliot F, Astagneau P, Fleury L, Brücker G, Bouvet E; CCLIN Paris-Nord Blood and Body Fluids(BBF) Exposure surveillance Taskforce. Occupational blood and body fluids exposures in health care workers: four-year surveillance from the Northern France network. Am J Infect Control 2003; 31(6): 357-63.

  26. Azap A, Ergönül O, Memikoğlu KO, Yeşilkaya A, Altunsoy A, Bozkurt GY, et al. Occupational exposure to blood and body fluids among health care workers in Ankara, Turkey. Am J Infect Control 2005; 33(1): 48-52.

  27. Abu-Gad HA, Al-Turki KA. Some epidemiological aspects of needle stick injuries among the hospital health care workers: Eastern Province, Saudi Arabia. Eur J Epidemiol 2001; 17(5):401-7.

  28. Bowman W, Bohnker BK. Needle-stick epidemiology in Navy health care workers based on INJTRAK reports (2001-2002). Mil Med 2005;170(12): 1034-6.

  29. Falagas ME, Karydis I, Kostogiannou I. Percutaneous exposure incidents of the health care personnel in a newly founded tertiary hospital: a prospective study. PLoS One 2007;2(2): e194.