Evaluation of Antibacterial and Antifungal Activities of Lepidium meyenii (Maca)

Document Type : Original Research

Authors
1 Department of Microbiology and Immunology, Qazvin University of Medical Science, Qazvin, Iran.
2 Biology Department, Karaj Branch, Islamic Azad University, Karaj, Iran
3 Department of Microbiology, Faculty of Medicine, Baqiatallah University of Medical Science, Tehran, Iran
4 Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
Abstract
Background: With increasing infectious diseases as well as antimicrobial resistance in pathogens to existing drugs, researchers are now seeking for new drug candidates to be used as alternatives or complementary therapies. Maca is commonly used in traditional medication as herbal medicine.

Materials & Methods: In this research, the antibacterial and antifungal activities of maca powder and ethanolic extract were evaluated against Staphylococcus aureus ATCC25923, Pseudomonas aeruginosa ATCC27853, Escherichia coli ATCC25922, Enterococcus faecalis ATCC29212, and Candida albicans ATCC10231 using Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and disc diffusion methods.

Results: The obtained results showed that there was no significant difference between the MIC and MBC of maca powder and extract against the reference and clinical strains. Also, no strain showed zone of inhibition at 30, 40, 50, and 60 µl of reference concentration.

Conclusion: According to the results obtained in this study, maca powder and extract had a poor inhibitory effect on bacterial and fungal growth.

Keywords


1. Ge Y, Difuntorum S, Touami S, Critchley I, Bürli R, Jiang V, et al. In vitro antimicrobial activity of GSQ1530, a new heteroaromatic polycyclic compound. Antimicrobial agents and chemotherapy. 2002;46(10):3168-74.
2. De Pasquale A. Pharmacognosy: the oldest modern science. Journal of ethnopharmacology. 1984;11(1):1-16.
3. Dixon RA. Natural products and plant disease resistance. Nature. 2001;411(6839):843.
4. Rates SMK. Plants as source of drugs. Toxicon. 2001;39(5):603-13.
5. Liu W, Xu S, Che C-T. Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. Life sciences. 2000;67(11):1297-306.
6. Popovich DG, Yeo C-R, Zhang W. Ginsenosides derived from Asian (Panax ginseng), American ginseng (Panax quinquefolius) and potential cytoactivity. International Journal of Biomedical and Pharmaceutical Sciences. 2012;6(1):56-62.
7. Ru W, Wang D, Xu Y, He X, Sun Y-E, Qian L, et al. Chemical constituents and bioactivities of Panax ginseng (CA Mey.). Drug discoveries & therapeutics. 2015;9(1):23-32.
8. Hermann M, Bernet T. The transition of maca from neglect to market prominence. Bioversity International. 2009;21.
9. Hermann M, Heller J. Andean roots and tubers at the crossroads. Andean roots and tubers: Ahipa, arracacha, maca and yacon Promoting the conservation and use of underutilized and neglected crops. 1997;21:5-11.
10. Martini N, Katerere D, Eloff J. Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae). Journal of ethnopharmacology. 2004;93(2-3):207-12.
11. Xue P, Yao Y, Yang X-s, Feng J, Ren G-x. Improved antimicrobial effect of ginseng extract by heat transformation. Journal of ginseng research. 2017;41(2):180-7.
12. Sung WS, Lee DG. The combination effect of Korean red ginseng saponins with kanamycin and cefotaxime against methicillin-resistant Staphylococcus aureus. Biological and Pharmaceutical Bulletin. 2008;31(8):1614-7.
13. Song Z, Wu H, Mathee K, Høiby N, Kharazmi A. Gerimax ginseng regulates both humoral and cellular immunity during chronic Pseudomonas aeruginosa lung infection. The Journal of Alternative & Complementary Medicine. 2002;8(4):459-66.