Studying the Relationship between COVID-19 and Clinical, Laboratory, and Demographic Data in Patients Referring to Shahid Rajaei Governmental Health Centers in Bandar Lengeh

Document Type : Original Research

Authors
M. Ghobahi 1
B. Heidari 2
M. Arfaatabar 3
E. Aghel 1
F. Rahimi 4
M. Yazdanpanah 1
S. Bagheri-Josheghani 5
Z. Fakhrieh-Kashan 6
1 Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical, Sciences Bandar Abbas, Iran.
2 Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical, Sciences Bandar Abbas, Iran
3 Department of Medical Laboratory Sciences, Kashan Branch, Islamic Azad University, Kashan, Iran
4 Shohada hospital, Hormozgan University of Medical, Sciences Bandar Abbas, Iran.
5 Vice Chancellor for Clinical Affairs, Kashan University of Medical Sciences, Kashan, Iran
6 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
10.52547/iem.8.1.35
Abstract
Background: Many factors are involved in the development of SARS-CoV-2 infection in individuals in each region, such as physiological conditions, underlying diseases, and observance of personal protection and hygiene; therefore, this study aimed to investigate factors affecting the incidence of COVID-19 in Bandar Lengeh, Hormozgan province, southern Iran.

Materials & Methods: Blood samples and demographic information were collected from suspected COVID-19 patients referring to Shahid Rajaei governmental health centers in Bandar Lengeh city. Hematological, biochemical, and serological tests were performed on the samples. PCR experiment was conducted to confirm SARS-CoV-2 infection. The thorax computed tomography (CT) was performed for all patients.

Findings: According to the PCR test results, the prevalence rate of SARS-CoV-2 infection was 26.92% among 130 individuals enrolled in this study. SARS-CoV-2 infection was more prevalent among clerks than in other occupational groups (p=0.017). Increased ESR (erythrocyte sedimentation rate) and decreased WBC (white blood cell), lymphocyte, and platelet counts were evident in COVID-19 patients. Also, the prevalence of COVID-19 infection was higher in patients with blood group A (33.3%) than in patients with other blood groups. The CRP (C-reactive protein) test was positive for 31 patients whose PCR test was positive for SARS-CoV-2. In addition, LDH (lactate dehydrogenase) level was higher in infected individuals compared to other participants (p=0.018).

Conclusion: In addition to the PCR test result, the most effective factors for diagnosing COVID-19 patients best on blood tests were as follows: increased CRP, ESR, and LDH levels and decreased WBC, lymphocyte, and platelet counts.

Keywords

Reference
1. Su S, Wong G, Shi W, Liu J, Lai AC, Zhou J, Liu W, Bi Y, Gao GF. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends in microbiology. 2016;24(6):490-502.
2. Cavanagh D. Coronavirus avian infectious bronchitis virus. Veterinary research. 2007;38(2):281-97.
3. Ismail MM, Tang Y, Saif YM. Pathogenicity of turkey coronavirus in turkeys and chickens. Avian diseases. 2003 ;47(3):515-22.
4. Su S, Wong G, Shi W, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol 2016; 24: 490-502.
5. Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 2019; 17: 181-92.
6. Zhong NS, Zheng BJ, Li YM, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February, 2003. Lancet 2003; 362: 1353-8.
7. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953-66.
8. Drosten C, Günther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348: 196776.
9. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012; 367: 1814-20.
10. Wong G, Liu W, Liu Y, Zhou B, Bi Y, Gao GF. MERS, SARS, and Ebola: the role of super-spreaders in infectious disease. Cell Host Microbe 2015; 18: 398-401.
11. Report of clustering pneumonia of unknown etiology in Wuhan City. Wuhan Municipal Health Commission, 2019. (http://wjw .wuhan .gov .cn/ front/ web/ showDetail/ 2019123108989
12. World Health Organization. Coronavirus. World Health Organization, cited January 19, 2020. Available: https://www.who.int/health-topics/coronavirus).
13. National Center for Immunization and Respiratory Diseases (NCIRD) DoVD. Coronavirus disease 2019 (COVID-19) situation summary: Centers for Disease Control and Prevention website.https://www.cdc.gov/coronavirus/2019nCoV/summary.html.UpdatedMarch21,2020.Accessed March 24, 2020.
14. Iranian Ministry of Health and Medical Education website.http://behdasht.gov.ir/. Updated 2020. Accessed March 24, 2020.
15. Yavarian J, Shafiei-Jandaghi N-Z, Sadeghi K, Malekshahi SS, Salimi V, Nejati A, et al. First cases of SARS-CoV-2 in Iran, 2020: case series report. Iranian Journal of Public Health. 2020;49(8):1564.
16. Identification of 743 cases of definitive new infections with Covid in the country Iranian Ministry of Health and Medical Education website. http://behdasht.gov.ir/index.jsp?siteid=1&fkeyid=&siteid=1&pageid=54782&newsview=200401. Published 2020. Accessed March 24, 2020.
17. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12(4):988.
18. Razzaque M. COVID-19 Pandemic: Can Maintaining Optimal Zinc Balance Enhance Host Resistance? 2020.
19. Zheng H-Y, Zhang M, Yang C-X, Zhang N, Wang X-C, Yang X-P, et al. Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients. Cellular & molecular immunology. 2020:1-3.
20. Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2020.
21. Fan BE, Chong VCL, Chan SSW, Lim GH, Lim KGE, Tan GB, et al. Hematologic parameters in patients with COVID‐19 infection. American Journal of Hematology. 2020.
22. Lan L, Xu D, Ye G, Xia C, Wang S, Li Y, et al. Positive RT-PCR test results in patients recovered from COVID-19. Jama. 2020.
23. Zhao J, Zhang Y, He X, Xie P. Covid-ct-dataset: a ct scan dataset about covid-19. arXiv preprint arXiv:200313865. 2020;490.
24. Mohammadzadeh N, Shahriary M, Shirmohammadlou N, Lohrasbi V. A glance at the prevalence of coronavirus disease 19 (COVID-19) in Iran: Strengths and weaknesses. Infection Control & Hospital Epidemiology. 2020; 41(12):1479-82.
25. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. New England journal of medicine. 2020.
26. Boudin L, Dutasta F. Relationship between ABO Blood Groups and Coronavirus Disease 2019: Study Design Matters. Clinical Infectious Diseases. 2020.
27. Han Y, Zhang H, Mu S, Wei W, Jin C, Tong C, et al. Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study. Aging (Albany NY). 2020; 12(12):11245.
28. Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging clinical and experimental research. 2020; 32(7):1195-8.
29. Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, et al. A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients. medRxiv. 2020.
30. Dos Santos LMJ. Can vitamin B12 be an adjuvant to COVID-19 treatment? GSC Biological and Pharmaceutical Sciences. 2020; 11(3):001-5.
31. Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z. Plasma CRP level is positively associated with the severity of COVID-19. Annals of clinical microbiology and antimicrobials. 2020; 19:1-7.
Infection Epidemiology and Microbiology
Volume 8, Issue 1
February 2022
Pages 35-42