Showing 4 results for Kidney Transplantation
Volume 2, Issue 1 (3-2016)
Abstract
Background:
The innate immunity plays an important role in the host response to transplantation by Toll-like receptors and results in development of acute allograft rejection. The aim of this study was to evaluate the association of TLR2 and CD14 (co-receptor) gene polymorphisms with acute rejection in kidney transplant recipients.
Methods
: The study was conducted in a population of 239 subjects consisting of 71 patients with acute rejection, 71 patients without acute rejection (SGF) and 97 Healthy Control (HC). The allele and genotype frequencies of TLR2 (R753Q, rs5743708) and CD14 (-159 C>T, rs2569190) polymorphisms were genotyped by Real-time PCR in the study groups.
Results
: Genotype distribution of CD14 -159 polymorphism was significantly different in AR vs. SGF and HC. CD14 -159 TT genotype was more prevalent in rejection than SGF and HC (P<0.0001, P<0.007, respectively). Also Graft loss, defiened as need of dialysis after acute rejection, was occurred in 24 patients (33.8%) from AR group. The frequencies of three genotype in CD14 (TT, CT, CC) in rejection With Graft loss were 75.0%, 20.8% and 4.1% respectively, While 25.5%, 31.9% and 42.5% in rejection without Graft loss (P<0.0001 for TT vs. CT, CC). Many recipients with AR were involved with graft loss had CD14 -159 TT genotype, whereas only a few recipients without graft loss had TT genotype (p<0.0001).
Conclusion
: Therefore, due to the importance of CD14 polymorphism (-159 C/T, rs2569190) in disease progression and also as a biomarker, could be considered as a crucial therapeutic target in early prognosis of acute rejection
Marzieh Eslami Kojidi, Somayeh Shatizadeh Malekshahi, Mohammad Reza Jabbari,
Volume 9, Issue 4 (12-2023)
Abstract
Aims: The purpose of this study is to evaluate the viral load of active human cytomegalovirus (HCMV) infection in the plasma samples of people suspected of kidney transplant rejection and to investigate the host and risk factors related to the activation of HCMV in these patients.
Materials & Methods: This cross-sectional study was conducted between December 2022 and June 2023. In this study, 98 blood samples related to patients suspected of kidney transplant rejection referring to Labbafinezhad hospital in Tehran were collected. The samples were tested by the GeneProof Cytomegalovirus (CMV) PCR Kit to determine HCMV viral load. ROC curve analysis was used to determine the viral load cutoff point.
Findings: HCMV viremia was detected in 18 (18.36%) of 98 transplant recipients. The median viral load in the HCMV viremia group was 24914.0 IU/ml (5147.0-155106.5). The optimal cut-off value for HCMV was determined 778 IU/ml using ROC analysis. Duration of time after transplantation in the viremia and no viremia groups was 120.5 and 46 months, respectively with a statistically significant difference (P=0.014).
Conclusion: This study provides valuable insights into the prevalence of HCMV viremia and its associated risk factors in kidney transplant recipients suspected of rejection. The study also highlights the importance of post-transplant monitoring and preventive measures to address viral infections. Quick and timely diagnosis of viral activation in kidney transplant patients is effective and mandatory for patient management and the use of appropriate preventive and therapeutic strategies that lead to the reduction of nephropathy, transplant rejection and other diseases. Long-term studies with larger sample sizes are needed to evaluate the role of factors influencing the occurrence of viremia after transplantation.
Volume 26, Issue 3 (9-2023)
Abstract
Kidney transplantation is one of the best treatment methods for people with chronic kidney failure, and a large number of kidney transplants are performed worldwide every year. Pathogens that commonly infect kidney transplant recipients are viruses, bacteria, and protozoa. Among these, viruses are considered one of the biggest life-threatening factors in kidney transplant recipients. The reactivation of herpesviruses from the latent state often occurs in conditions of weakening the immune system, including after kidney transplantation. Infection with herpesviruses is still one of the main causes of complications and death for most kidney transplant recipients. Rapid diagnosis of active infection of these viruses in kidney transplant patients has a significant impact on the use of appropriate treatment strategies to reduce complications and transplant rejection. For this reason, this review aims to provide information about the preventive strategies, diagnosis, and treatment of herpesviruses infections in kidney transplant recipients. In this brief review, we have updated the information presented in previous articles and adjusted it based on recent advances, updated clinical guidelines, and common post-transplant tactics to minimize the risk of infection.
Volume 27, Issue 2 (11-2024)
Abstract
Background: The health-related quality of life in patients who have received kidney transplants plays a crucial role in determining the timing of their dialysis initiation and their involvement in family and community settings. Consequently, this study was conducted to evaluate the quality of life among kidney transplant recipients.
Method: This research is a retrospective descriptive-analytical study involving patients who have undergone kidney transplantation within the past year, carried out at Golestan and Imam Khomeini Ahvaz hospitals. A specific questionnaire, the KDQOL-SF, was employed to gather data on the quality of life of these patients. The study comprised 27 participants who were at least 6-months post-transplant.
Results: The results indicated that the overall quality of life among the participants was average, with those who were one-year post-transplant reporting improved quality of life scores. It was observed that men and married individuals had significantly higher quality of life scores compared to their female and single counterparts. Furthermore, participants aged 26 to 30 years exhibited the highest quality of life scores, and a significant positive correlation was found between quality of life and the level of social support received by kidney transplant patients.
Conclusion: In summary, the findings of this study suggest that the quality of life for kidney transplant recipients is generally average, with notable improvements occurring one year after the procedure. Additionally, demographic factors such as gender, marital status, and age, along with the presence of social support, are significant determinants of quality of life in this demographic.
