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Background: Nocardia as a Gram-positive bacillus with a microscopic appearance of branching hyphae can produce considerable disease in an appropriable host. N. facinica is a member of genus Nocardia that is potentially life threatening; therefore, therapy of N. farcinica infection remains difficult.
Case presentation: This study is a case  report of disseminated N. farcinica infection in a 64-year-old man with a history of pneumoconiosis with brain, lung, and skin involvement in Labbafi Nejad hospital, Tehran, IR Iran in November 2013 with a discussion about diagnosis and management of this particular patient.
Conclusion: Due to the involvement of brain, triple therapy was started with meropenem, amikacin, and linezolid.