Volume 6, Issue 3 (2020)
IEM 2020, 6(3): 229-249 |
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Mohammadi Barzelighi H, Daraei B. The Review of SARS-CoV-2: Recent Perspective and Advances in Detection. IEM 2020; 6 (3) :229-249
URL: http://iem.modares.ac.ir/article-4-45899-en.html
URL: http://iem.modares.ac.ir/article-4-45899-en.html
1- Biosun Pharmed Factory, Barkat Pharmaceutical group, Tehran, Iran
2- Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran , bdaraei@sbmu.ac.ir
2- Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran , bdaraei@sbmu.ac.ir
Abstract: (1195 Views)
Background: The outbreak of novel coronavirus (2019-nCoV), which began in Wuhan, China, has rapidly spread in many countries and is currently considered a pandemic. The virus (SARS-CoV-2) causes severe acute respiratory syndrome and is related to SARS-CoV and MERS-CoV.
Methods: In this review, an introduction to SARS-CoV-2 was provided comprising the following items: general features; pathogenesis; the existing knowledge on immunological properties; transmission routs; diagnostic features, especially discussion about new approaches for treatment and prevention; and different diagnostic methods including nucleic acid based assays, serological testing, and MALDI TOF-MS and LC-MS technologies.
Findings and Conclusion: Introducing the different methods for SARS-CoV-2 detection may be useful to provide new insights into the development and improvement of detection primers, probes, methods/techniques, potential targets for drug designation, and therapeutic candidates against the virus.
Methods: In this review, an introduction to SARS-CoV-2 was provided comprising the following items: general features; pathogenesis; the existing knowledge on immunological properties; transmission routs; diagnostic features, especially discussion about new approaches for treatment and prevention; and different diagnostic methods including nucleic acid based assays, serological testing, and MALDI TOF-MS and LC-MS technologies.
Findings and Conclusion: Introducing the different methods for SARS-CoV-2 detection may be useful to provide new insights into the development and improvement of detection primers, probes, methods/techniques, potential targets for drug designation, and therapeutic candidates against the virus.
Keywords: 2019-nCoV, Acute Respiratory syndrome, Nucleic acid base assays, Serological testing, MALDI TOF-MS and LC-MS
Article Type: Analytic Review |
Subject:
Bacteriology
Received: 2020/09/10 | Accepted: 2020/10/2 | Published: 2020/08/30
Received: 2020/09/10 | Accepted: 2020/10/2 | Published: 2020/08/30
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