Volume 7, Issue 3 (2021)                   IEM 2021, 7(3): 237-244 | Back to browse issues page

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Somé E N, Guingané A N, Zongo I, Ouédraogo M L, Drabo M, Sombié R. Epidemiological and Clinical Characteristics of Inactive Carriers of Hepatitis B Virus: A Descriptive Cross-Sectional Study in Burkina Faso. IEM 2021; 7 (3) :237-244
URL: http://iem.modares.ac.ir/article-4-50991-en.html
1- Institut de Recherche en Sciences de la Santé (IRSS), Biomedical and public health department, Ouagadougou, Burkina Faso , eric.some@gmail.com
2- University Joseph Ki-Zerbo, UFR/SdS, gastro-enterology department-Zerbo, UFR/SdS, gastro-enterology department
3- Institut de Recherche en Sciences de la Santé (IRSS), Biomedical and public health department, Ouagadougou, Burkina Faso
Abstract:   (1200 Views)
Backgrounds: This study aimed to describe the epidemiological and clinical characteristics of inactive HBV chronic carriers at the gastroenterology department of the university teaching hospital Yalgado Ouedraogo.
Materials & Methods: This descriptive cross-sectional study was conducted from January 1, 2007 to December 31, 2014 by employing a prospective data collection method. It was a census of all cases meeting the eligibility criteria. All patients with chronic viral hepatitis B (VHB) and ≥15 years of age and presenting the following signs were included in this study: positive result on hepatitis B surface antigen test for at least 6 months, normal levels of alanine amino-transferase for at least one year, positive anti-HBe antibodies, negative HBeAg, and viral DNA < 20,000 IU/mL.
Findings: The mean age of patients was 35 years, and the mean duration of HBsAg carriage was 6 years. The physical examination was normal in all participants. Ultrasound exam was normal in 150 (92.6%) participants and showed a fatty liver in 12 (7.4%) participants. Overall 4.4% of participants developed severe fibrosis, and no patient developed cirrhosis. The main indications for drug treatment included the existence of a family history of hepatocellular carcinoma (36.7%), the presence of active hepatitis (33.3%), and the progression of the fibrosis (30%).
Conclusion: This study confirms the importance of close follow up of HBV-infected patients to dramatically reduce the risk of developing complications such as cirrhosis or hepatocellular carcinoma.
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Article Type: Descriptive & Survey | Subject: Virology
Received: 2021/03/16 | Accepted: 2021/05/23 | Published: 2021/07/31

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