Volume 8, Issue 3 (2022)                   IEM 2022, 8(3): 0-0 | Back to browse issues page

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Moradi M, Khashei R, Malekzadegan Y, Sarvari J. Emergence of OXA-10 and OXA-48 Like Carbapenemases among Enterobacter Isolates from Inpatients in Namazi Hospital in Shiraz. IEM 2022; 8 (3)
URL: http://iem.modares.ac.ir/article-4-58929-en.html
1- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , re.khashei@gmail.com
Abstract:   (151 Views)
Backgrounds: The global spread of carbapenemase-producing Enterobacteriaceae represents a public health concern. This study aimed to investigate the prevalence of carbapenem resistance and the presence of some oxacillinase types and class 1-3 integrons among Enterobacter clinical isolates from an Iranian inpatient population.
Materials & Methods: Ninety Enterobacter isolates from hospitalized patients were diagnosed by microbiological methods. Antibiogram pattern was also determined. The presence of class 1-3 integrons and four types of oxacillinase genes was assessed using PCR.
Findings: Among 90 Enterobacter isolates, the most common species was E. aerogenes, (45.6%), followed by E. cloacae (30%). The highest resistance rate was against ampicillin (96.7%). Multi-drug resistance (MDR) was substantial (93%). Carbapenemase-producers were detected in 96% of carbapenem-resistant isolates by mCIM test. The frequency of evaluated genes was as follows: intI1 = 50 (55.6%), intI2 =12 (13.3%), blaoxa-1 =6 (6.7%), blaoxa-2 =5 (5.6%), blaoxa-10 =18 (20%), and blaoxa-48 =18 (20%).
Conclusion: Determinants of class 1 integron along with OXA-10 and OXA-48 like carbapememases are responsible for relatively considerable carbapenem resistance among isolates. This is the first report about the presence of OXA-10 and OXA-48-producing Enterobacter spp. in Iran, indicating that the prevalence of oxacillinases in the country might be on the rise.    

 
     
Article Type: Original Research | Subject: Bacteriology
Received: 2022/01/23 | Accepted: 2022/09/3 | Published: 2022/09/19

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