Volume 9, Issue 1 (2023)                   IEM 2023, 9(1): 35-42 | Back to browse issues page


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AL-Khikani F H O, Abdulridha Alkhafaji Z. Impact of IL-35 and presepsin on immunological, hematological, and biochemical parameters in COVID-19 patients. IEM 2023; 9 (1) :35-42
URL: http://iem.modares.ac.ir/article-4-64052-en.html
1- Department of biology, Sanandaj branch, Islamic azad university, Sanandaj, Iran , falahgh38@gmail.com
2- Department of Microbiology, College of Medicine, University of Babylon, Hilla, Iraq.
Abstract:   (940 Views)
Backgrounds: Immune-inflammatory responses appear to play a key role in severe SARS-CoV-2 infections. Interleukin-35 (IL-35) and presepsin (PSN) are inhibitory cytokine and pro-inflammatory interleukin, which play a crucial role in the immune system modulation, respectively. Therefore, the study of IL-35 and PSN interaction with other parameters may be critical for managing patients with COVID-19.
Materials & Methods: A total of 125 severe/critical COVID-19 patients and 60 healthy persons as a control group were enrolled in this work. These patients were admitted to Marjan medical city and Al-Sadeq hospital in Iraq during February to August 2022 and diagnosed as severe cases depending on the SpO2 percentage according to the guidelines released by the National Health World. Anti- and pro-inflammatory cytokines (IL-35 and PSN) were detected by ELISA technique.
Findings: Presepsin showed a positive correlation with admission to the respiratory care unit (RCU) (r= .022, p= .011). A negative correlation was found between presepsin and C- reactive protein (CRP) (r= .21, p= .018). Both PSN and IL-35 in biochemical tests showed a positive strong effect on glucose levels in COVID-19 patients (r= .234, p= .008 and r= .241, p= .007, respectively). IL-35 had a positive impact on alkaline phosphatase (ALP) (r= .28, p= .002). Hemoglobin (Hb) level showed a positive correlation with presepsin (r= .2, p= .02).
Conclusion: This study confirms the growing evidence showing the direct role of regulatory pro-inflammatory cytokines in the development and control of COVID-19 through the interaction with other parameters.
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Article Type: Original Research | Subject: Virology
Received: 2022/09/6 | Accepted: 2022/12/2 | Published: 2023/03/10

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