Volume 9, Issue 1 (2023)
IEM 2023, 9(1): 0-0 |
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AL-Khikani F H O. Impact of IL-35 and presepsin on immunological, hematological, and biochemical parameters in COVID-19 patients. IEM 2023; 9 (1)
URL: http://iem.modares.ac.ir/article-4-64052-en.html
URL: http://iem.modares.ac.ir/article-4-64052-en.html
Dept. of Microbiology/ College of Medicine / University of Babylon, Hilla, Iraq , falahgh38@gmail.com
Abstract: (185 Views)
Aims: The immune-inflammatory response appears to play a key role in severe SARS-CoV-2 infections. Interleukin-35 (IL-35) and presepsin (PSN) are inhibitory cytokine and pro-inflammatory interleukin respectively that play a crucial role in the immune system modulation. As a result, the study of IL-35 and PSN interaction with other parameters may be critical to managing patients with COVID-19.
Materials & methods: A total of 125 severe/critical COVID-19 patients were involved in this work as well as 60 persons enrolled as a control group. Between February 2022 and august 2022, these patients were admitted to Marjan medical city and Al-Sadeq hospital. Patients were determined as severe cases according to the guidelines released by National Health World depending on SpO2 percentage. The inflammatory cytokine (IL-35 and PSN) was detected by the ELISA technique.
Findings: Presepsin showed a positive correlation with admission to the respiratory care unit (RCU) (r= 0.022, P= 0.011). A negative correlation between presepsin and C- reactive protein (CRP) (r= 0.21; P= 0.018) was observed. The impact of both PSN and IL-35 on biochemical tests showed a positive strong impact on glucose levels in COVID-19 patients as (r= 0.234; P= 0.008) and (r= 0.241; P= 0.007) respectively. A positive impact correlation of IL-35 was observed on alkaline phosphatase (ALP) (r= 0.28; P= 0.002). Hemoglobin (Hb) level showed a positive correlation with presepsin (r= 0.2; P= 0.02).
Conclusion: This study confirms the growing evidence of the direct role of regulatory pro-inflammatory cytokines in the development and controlling COVID-19 through the interaction of these cytokines with other parameters.
Materials & methods: A total of 125 severe/critical COVID-19 patients were involved in this work as well as 60 persons enrolled as a control group. Between February 2022 and august 2022, these patients were admitted to Marjan medical city and Al-Sadeq hospital. Patients were determined as severe cases according to the guidelines released by National Health World depending on SpO2 percentage. The inflammatory cytokine (IL-35 and PSN) was detected by the ELISA technique.
Findings: Presepsin showed a positive correlation with admission to the respiratory care unit (RCU) (r= 0.022, P= 0.011). A negative correlation between presepsin and C- reactive protein (CRP) (r= 0.21; P= 0.018) was observed. The impact of both PSN and IL-35 on biochemical tests showed a positive strong impact on glucose levels in COVID-19 patients as (r= 0.234; P= 0.008) and (r= 0.241; P= 0.007) respectively. A positive impact correlation of IL-35 was observed on alkaline phosphatase (ALP) (r= 0.28; P= 0.002). Hemoglobin (Hb) level showed a positive correlation with presepsin (r= 0.2; P= 0.02).
Conclusion: This study confirms the growing evidence of the direct role of regulatory pro-inflammatory cytokines in the development and controlling COVID-19 through the interaction of these cytokines with other parameters.
Article Type: Original Research |
Subject:
Virology
Received: 2022/09/6 | Accepted: 2022/12/2 | Published: 2023/03/10
Received: 2022/09/6 | Accepted: 2022/12/2 | Published: 2023/03/10
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