Volume 10, Issue 3 (2024)
IEM 2024, 10(3): 0-0 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Abolbashari S, mirzaei S M S, Khoshakhllagh M, Sokhtanloo Z, Aryan E, Berenji F, et al . Association between Toxoplasma gondii Infection and Multiple Sclerosis. IEM 2024; 10 (3)
URL: http://iem.modares.ac.ir/article-4-70324-en.html
URL: http://iem.modares.ac.ir/article-4-70324-en.html
Samaneh Abolbashari1 
, Seyyd mohammad sadegh Mirzaei2 , Mahdieh Khoshakhllagh3 , Zahra Sokhtanloo3 , Ehsan Aryan4 , Fariba Berenji5 , Mojtaba Meshkat6 , Reza Boostani7 , Zahra Meshkat1 , Amin Hooshyar Chechaklou1 , Mansoureh Bakhshi8 , Aida Gholoobi * 9
, Seyyd mohammad sadegh Mirzaei2 , Mahdieh Khoshakhllagh3 , Zahra Sokhtanloo3 , Ehsan Aryan4 , Fariba Berenji5 , Mojtaba Meshkat6 , Reza Boostani7 , Zahra Meshkat1 , Amin Hooshyar Chechaklou1 , Mansoureh Bakhshi8 , Aida Gholoobi * 9
1- Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Biochemistry, Faculty of Science, Mashhad Branch, Islamic Azad University Mashhad, Iran
4- Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5- Department of Parasitology and Mycology, Emam Reza Hospital, Mashhad University of Medical Sciences, Iran.
6- Department of Community Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
7- Department of Neurology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8- Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
9- Metabolic Syndrome Research Center and Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, and Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ,gholoubiad@mums.ac.ir
2- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Biochemistry, Faculty of Science, Mashhad Branch, Islamic Azad University Mashhad, Iran
4- Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5- Department of Parasitology and Mycology, Emam Reza Hospital, Mashhad University of Medical Sciences, Iran.
6- Department of Community Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
7- Department of Neurology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8- Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
9- Metabolic Syndrome Research Center and Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, and Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (298 Views)
Backgrounds: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system. Toxoplasma gondii infection is one of the risk factors of MS. Knowing the correlation between T. gondii infection and MS could lead to a better understanding of the disease incidence. This study aimed to assess the correlation between T. gondii infection and the disease incidence in infected individuals.
Materials & Methods: Serum samples of 38 MS patients referring to the neurology clinic of Ghaem hospital in Mashhad in 2019 were analyzed by Pishtazteb commercial kit for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assay (ELISA). The obtained data were analyzed with SPSS software Version 20.
Findings: Among the 79 tested individuals, 22 were positive, and 57 were negative for anti-T. gondii IgG antibodies. Among the negative cases, 29 (50.9%) had MS, and 28 (49.1%) were controls. Among the positive cases, nine (40.9%) patients had MS, and the remaining 13 (59.1%) were controls. The frequency of IgG antibody in the case and control groups was not significantly different (p= .427). Anti-T. gondii IgM antibody was negative in all samples. There was no significant difference between the types of MS regarding the frequency of anti-T. gondii antibodies (p= .402).
Conclusion: No significant difference was found in the frequency of anti-T. gondii IgG antibodies between the two groups. However, further studies with larger sample sizes are recommended to gain a better understanding of the relationship between anti-T. gondii IgG antibody positivity and MS incidence
Materials & Methods: Serum samples of 38 MS patients referring to the neurology clinic of Ghaem hospital in Mashhad in 2019 were analyzed by Pishtazteb commercial kit for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assay (ELISA). The obtained data were analyzed with SPSS software Version 20.
Findings: Among the 79 tested individuals, 22 were positive, and 57 were negative for anti-T. gondii IgG antibodies. Among the negative cases, 29 (50.9%) had MS, and 28 (49.1%) were controls. Among the positive cases, nine (40.9%) patients had MS, and the remaining 13 (59.1%) were controls. The frequency of IgG antibody in the case and control groups was not significantly different (p= .427). Anti-T. gondii IgM antibody was negative in all samples. There was no significant difference between the types of MS regarding the frequency of anti-T. gondii antibodies (p= .402).
Conclusion: No significant difference was found in the frequency of anti-T. gondii IgG antibodies between the two groups. However, further studies with larger sample sizes are recommended to gain a better understanding of the relationship between anti-T. gondii IgG antibody positivity and MS incidence
Article Type: Original Research |
Subject:
Parasitology
Received: 2023/07/6 | Accepted: 2024/06/11 | Published: 2024/08/20
Received: 2023/07/6 | Accepted: 2024/06/11 | Published: 2024/08/20
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |