Volume 10, Issue 3 (2024)
IEM 2024, 10(3): 245-252 |
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Abolbashari S, mirzaei S M S, Khoshakhlagh M, Sokhtanloo Z, Aryan E, Berenji F, et al . Association between Toxoplasma gondii Infection and Multiple Sclerosis. IEM 2024; 10 (3) :245-252
URL: http://iem.modares.ac.ir/article-4-70324-en.html
URL: http://iem.modares.ac.ir/article-4-70324-en.html
Samaneh Abolbashari1 
, Seyyd mohammad sadegh Mirzaei2 , Mahdieh Khoshakhlagh3 , Zahra Sokhtanloo4 , Ehsan Aryan5 , Fariba Berenji6 , Mojtaba Meshkat7 , Reza Boostani8 , Zahra Meshkat1 , Amin Hooshyar Chechaklou1 , Mansoureh Bakhshi9 , Aida Gholoobi * 10
, Seyyd mohammad sadegh Mirzaei2 , Mahdieh Khoshakhlagh3 , Zahra Sokhtanloo4 , Ehsan Aryan5 , Fariba Berenji6 , Mojtaba Meshkat7 , Reza Boostani8 , Zahra Meshkat1 , Amin Hooshyar Chechaklou1 , Mansoureh Bakhshi9 , Aida Gholoobi * 10
1- Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Biochemistry, Faculty of Science, Mashhad Branch, Islamic Azad University Mashhad, Iran
5- Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6- Department of Medical Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7- Department of Community Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
8- Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
9- Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
10- Metabolic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ,gholoubiad@mums.ac.ir
2- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Biochemistry, Faculty of Science, Mashhad Branch, Islamic Azad University Mashhad, Iran
5- Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6- Department of Medical Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7- Department of Community Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
8- Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
9- Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
10- Metabolic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (896 Views)
Background: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system. Toxoplasma gondii infection is one of the risk factors of MS. Knowing the correlation between T. gondii infection and MS could lead to a better understanding of the disease incidence. This study aimed to assess the correlation between T. gondii infection and the disease incidence in infected individuals.
Materials & Methods: Serum samples of 38 MS patients referring to the neurology clinic of Ghaem hospital in Mashhad in 2019 were analyzed by Pishtazteb commercial kit for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assay (ELISA). The obtained data were analyzed with SPSS software Version 20.
Findings: Among the 79 tested individuals, 22 were positive, and 57 were negative for anti-T. gondii IgG antibodies. Among the negative cases, 29 (50.9%) had MS, and 28 (49.1%) were controls. Among the positive cases, nine (40.9%) patients had MS, and the remaining 13 (59.1%) were controls. The frequency of IgG antibody in the case and control groups was not significantly different (p= .427). Anti-T. gondii IgM antibody was negative in all samples. There was no significant difference between the types of MS regarding the frequency of anti-T. gondii antibodies (p= .402).
Conclusion: No significant difference was found in the frequency of anti-T. gondii IgG antibodies between the two groups. However, further studies with larger sample sizes are recommended to gain a better understanding of the relationship between anti-T. gondii IgG antibody positivity and MS incidence
Materials & Methods: Serum samples of 38 MS patients referring to the neurology clinic of Ghaem hospital in Mashhad in 2019 were analyzed by Pishtazteb commercial kit for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assay (ELISA). The obtained data were analyzed with SPSS software Version 20.
Findings: Among the 79 tested individuals, 22 were positive, and 57 were negative for anti-T. gondii IgG antibodies. Among the negative cases, 29 (50.9%) had MS, and 28 (49.1%) were controls. Among the positive cases, nine (40.9%) patients had MS, and the remaining 13 (59.1%) were controls. The frequency of IgG antibody in the case and control groups was not significantly different (p= .427). Anti-T. gondii IgM antibody was negative in all samples. There was no significant difference between the types of MS regarding the frequency of anti-T. gondii antibodies (p= .402).
Conclusion: No significant difference was found in the frequency of anti-T. gondii IgG antibodies between the two groups. However, further studies with larger sample sizes are recommended to gain a better understanding of the relationship between anti-T. gondii IgG antibody positivity and MS incidence
Article Type: Original Research |
Subject:
Parasitology
Received: 2023/07/6 | Accepted: 2024/06/11 | Published: 2024/08/20
Received: 2023/07/6 | Accepted: 2024/06/11 | Published: 2024/08/20
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