Volume 9, Issue 3 (2023)
IEM 2023, 9(3): 257-263 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
shayestehpour M, Ebneali F, Zamani B, Piroozmand A, Esalatmanesh K, Fateminasab Z et al . Association between Torque Teno Virus Frequency and Systemic Lupus Erythematosus: A Potential Trigger for Autoimmune Diseases. IEM 2023; 9 (3) :257-263
URL: http://iem.modares.ac.ir/article-4-70735-en.html
URL: http://iem.modares.ac.ir/article-4-70735-en.html
Mohammad Shayestehpour * 
1, Faezeh Ebneali2 , Batool Zamani3 , Ahmad Piroozmand3 , Kamal Esalatmanesh3 , Zahrasadat Fateminasab2 , Shaghayegh Yazdani4
1, Faezeh Ebneali2 , Batool Zamani3 , Ahmad Piroozmand3 , Kamal Esalatmanesh3 , Zahrasadat Fateminasab2 , Shaghayegh Yazdani4
1- Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran , shayestehpour-m@kaums.ac.ir
2- Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
3- Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
4- Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
3- Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
4- Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (1002 Views)
Background: Infectious agents are considered as one of the possible etiological factors of systemic lupus erythematosus (SLE). It has been suggested that torque teno virus (TTV) may trigger autoimmune disorders, but few studies have been conducted on the relationship between this virus and autoimmune diseases, especially SLE. The present study aimed to evaluate the association between TTV frequency and SLE.
Materials & Methods: Serum samples were collected from a total of 116 participants, including 58 healthy people and 58 SLE patients who referred to the rheumatology clinic of Shahid-Beheshti hospital in Kashan, Iran from January 2020 to January 2021. After the extraction of viral DNA from the samples, a nested PCR test was performed using specific primers to detect TTV.
Findings: TTV was detected in 43 SLE patients (74.1%, 95% CI: 63.4-86.2) and 33 healthy individuals (56.9%, 95% CI: 44.1-69.0). A significant correlation was found between SLE and the presence of TTV (r= .32, p= .03). There was no correlation between the presence of TTV and musculoskeletal involvements, skin lesions, renal manifestations, and hematological manifestations (r< .05, p> .05). TTV was detected more frequently in patients with active lupus than in patients with quiescent disease, and this difference was significant (p= .048).
Conclusion: A significant association between TTV and SLE was observed in the present study; however, further studies are needed to investigate the role of TTV in the pathogenesis and clinical course of SLE.
Materials & Methods: Serum samples were collected from a total of 116 participants, including 58 healthy people and 58 SLE patients who referred to the rheumatology clinic of Shahid-Beheshti hospital in Kashan, Iran from January 2020 to January 2021. After the extraction of viral DNA from the samples, a nested PCR test was performed using specific primers to detect TTV.
Findings: TTV was detected in 43 SLE patients (74.1%, 95% CI: 63.4-86.2) and 33 healthy individuals (56.9%, 95% CI: 44.1-69.0). A significant correlation was found between SLE and the presence of TTV (r= .32, p= .03). There was no correlation between the presence of TTV and musculoskeletal involvements, skin lesions, renal manifestations, and hematological manifestations (r< .05, p> .05). TTV was detected more frequently in patients with active lupus than in patients with quiescent disease, and this difference was significant (p= .048).
Conclusion: A significant association between TTV and SLE was observed in the present study; however, further studies are needed to investigate the role of TTV in the pathogenesis and clinical course of SLE.
Article Type: Original Research |
Subject:
Virology
Received: 2023/07/24 | Accepted: 2023/10/9 | Published: 2023/10/18
Received: 2023/07/24 | Accepted: 2023/10/9 | Published: 2023/10/18
References
1. 1. Zamani B, Moeini Taba SM, Shayestehpour M. Systemic lupus erythematosus manifestation following COVID-19: A case report. J Med Case Rep. 2021;15(1):1-4. [DOI:10.1186/s13256-020-02582-8] [PMID] []
2. Zamani B, Shayestehpour M, Esfahanian F, Akbari H. The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus. BMC Res Notes. 2020;13(1):1-6. [DOI:10.1186/s13104-020-05039-9] [PMID] []
3. Moustafa AT, Moazzami M, Engel L, Bangert E, Hassanein M, Marzouk S, et al. Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis. Semin Arthritis Rheum. 2020;50(1):84-94. [DOI:10.1016/j.semarthrit.2019.06.017] [PMID]
4. Iwata S, Tanaka Y. Association of viral infection with the development and pathogenesis of systemic lupus erythematosus. Front Med. 2022;9:849120. [DOI:10.3389/fmed.2022.849120] [PMID] []
5. Shayestehpour M, Zamani B. The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection. Eur Rev Med Pharmacol Sci. 2020;24(22):11474.
6. Shayestehpour M, Zamani B. Systemic lupus erythematosus and varicella‐like rash following COVID‐19 in a previously healthy patient. J Med Virol. 2021;93(5):2599. [DOI:10.1002/jmv.26838] [PMID] []
7. Zhao J, You X, Zeng X. Research progress of BK virus and systemic lupus erythematosus. Lupus. 2022;31(5):522-31. [DOI:10.1177/09612033221084259] [PMID]
8. Quaglia M, Merlotti G, De Andrea M, Borgogna C, Cantaluppi V. Viral infections and systemic lupus erythematosus: New players in an old story. Viruses. 2021;13(2):277. [DOI:10.3390/v13020277] [PMID] []
9. Jog NR, James JA. Epstein Barr virus and autoimmune responses in systemic lupus erythematosus. Front Immunol. 2021;11:623944. [DOI:10.3389/fimmu.2020.623944] [PMID] []
10. Blazsek A, Sillo P, Ishii N, Gergely Jr P, Poor G, Preisz K, et al. Searching for foreign antigens as possible triggering factors of autoimmunity: Torque teno virus DNA prevalence is elevated in sera of patients with bullous pemphigoid. Exp Dermatol. 2008;17(5):446-54. [DOI:10.1111/j.1600-0625.2007.00663.x] [PMID]
11. Siahpoush M, Noorbazargan H, Kalantari S, Shayestehpour M, Yazdani S. Coinfection of torque teno virus (TTV) and human papillomavirus (HPV) in cervical samples of women living in Tehran, Iran. Iran J Microbiol. 2022;14(2):181-5. [DOI:10.18502/ijm.v14i2.9185] [PMID] []
12. Moghimi M, Shayestehpour M, Doosti M, Vasmehjani AA, Ahmadi AS, Akhondi-Meybodi M. Prevalence of torque teno virus in healthy individuals and those infected with hepatitis C virus living in Yazd, Iran. Caspian J Intern Med. 2020;11(2):199-204.
13. Webb B, Rakibuzzaman A, Ramamoorthy S. Torque teno viruses in health and disease. Virus Res. 2020;285:198013. [DOI:10.1016/j.virusres.2020.198013] [PMID]
14. Swedan S, Al-Saleh D. Transfusion transmitted virus and dengue virus among healthy blood donors: A prevalence report from Jordan. Biomol Biomed. 2023;23(3):450-6. [DOI:10.17305/bjbms.2022.7832]
15. Gergely Jr P, Pullmann R, Stancato C, Otvos Jr L, Koncz A, Blazsek A, et al. Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus. Clin Immunol. 2005;116(2):124-34. [DOI:10.1016/j.clim.2005.04.002] [PMID]
16. Costa MR, Costa IP, Devalle S, Castro AR, Freitas SZ. Prevalence and genetic diversity of torque teno virus in patients with systemic lupus erythematosus in a reference service in Mato Grosso do Sul. Rev Bras Reumatol. 2012;52(1):49-54. [DOI:10.1590/S0482-50042012000100006] [PMID]
17. Petri M. Review of classification criteria for systemic lupus erythematosus. Rheum Dis Clin. 2005;31(2):245-54. [DOI:10.1016/j.rdc.2005.01.009] [PMID]
18. Seemayer C, Viazov S, Neidhart M, Brühlmann P, Michel B, Gay R, et al. Prevalence of TTV DNA and GBV-C RNA in patients with systemic sclerosis, rheumatoid arthritis, and osteoarthritis does not differ from that in healthy blood donors. Ann Rheum Dis. 2001;60(8):806-9. [DOI:10.1136/ard.60.8.806] [PMID] []
19. Shirai T, Hirose S. Molecular pathogenesis of SLE. Springer Semin Immunopathol. 2006;28(2):79-82. [DOI:10.1007/s00281-006-0032-5] [PMID]
20. Kooistra K, Zhang YH, Henriquez NV, Weiss B, Mumberg D, Noteborn MH. TT virus-derived apoptosis-inducing protein induces apoptosis preferentially in hepatocellular carcinoma-derived cells. J Gen Virol. 2004;85(6):1445-50. [DOI:10.1099/vir.0.79790-0] [PMID]
21. Table1. Frequency of TTV among SLE patients and the control group
22. Group TTV Positive TTV Negative P Value
23. SLE 43 (74.1%) 15 (25.8%) .03
24. Control 33 (56.9%) 25 (43.1%)
25. Table 2. Frequency of TTV among SLE patients according to the clinical signs, lupus activity, and disease duration
26. Characteristic TTV Positive N(%) TTV
27. Negative N(%) P Value
28. Clinical sign Musculoskeletal involvement 35 (73) 13 (27) .09
29. Skin lesion 21 (70) 9 (30) .14
30. Renal manifestation 14 (70) 6 (30) .17
31. Hematological manifestation 17 (74) 6 (26) .19
32. Lupus activity 32 (74) 11 (26) .048
33. Disease duration (mean year ± sd) 6.3±3.5 5.9±3.7 0.97
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |