Volume 10, Issue 3 (2024)
IEM 2024, 10(3): 0-0 |
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Erfani S, Zare Bidaki M, Alemzadeh E, Ebrahimzadeh A. Bacterial Spectrum and Antimicrobial Susceptibility Patterns in Septicemia Suspected Patients. IEM 2024; 10 (3)
URL: http://iem.modares.ac.ir/article-4-72999-en.html
URL: http://iem.modares.ac.ir/article-4-72999-en.html
1- Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2- Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
3- Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran ,mr14436@yahoo.com
2- Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
3- Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran ,
Abstract: (221 Views)
Backgrounds: In this comprehensive study, the prevalence of sepsis, a potentially life-threatening condition, was investigated among 477 patients displaying sepsis symptoms.
Materials & Methods: A detailed questionnaire was used to capture the patients' demographic information and clinical treatment outcomes.The E-test method was employed to determine the susceptibility of Gram-positive bacteria to vancomycin and Gram-negative bacteria to cefepime, ceftriaxone, and imipenem.
Findings: Among the participants, 40 patients (8.6%) were diagnosed with septicemia, a condition whose prevalence significantly increased with age (p= .001). Out of 40 patients with positive blood cultures, 14 (35%) were infected by Gram-positive bacteria, while 26 (65%) were infected by Gram-negative bacteria. Acinetobacter lwoffii and Staphylococcus epidermidis were identified as the most common causes of sepsis among Gram-negative (30.7%) and Gram-positive (57.1%) bacteria, respectively Gram-negative bacteria exhibited the highest resistance to ceftriaxone (38.4%) and the highest susceptibility to imipenem (84.6%) in both laboratory and clinical settings. Gram-positive bacteria demonstrated the high susceptibility to vancomycin (78.5%), with only four patients exhibiting resistance to vancomycin in both laboratory and clinical settings. Encouragingly, there was a 77.5% concordance between laboratory and clinical antibiotic susceptibility testing results.
Conclusion: Based on these findings, vancomycin and imipenem are recommended as the preferred antibiotics for Gram-positive and Gram-negative bacteria, respectively. Given the high concordance (77.5%) between laboratory and clinical results, it is suggested to perform antibiogram test using E-test method on blood culture isolates in septicemia cases to guide appropriate antibiotic treatment.
Materials & Methods: A detailed questionnaire was used to capture the patients' demographic information and clinical treatment outcomes.The E-test method was employed to determine the susceptibility of Gram-positive bacteria to vancomycin and Gram-negative bacteria to cefepime, ceftriaxone, and imipenem.
Findings: Among the participants, 40 patients (8.6%) were diagnosed with septicemia, a condition whose prevalence significantly increased with age (p= .001). Out of 40 patients with positive blood cultures, 14 (35%) were infected by Gram-positive bacteria, while 26 (65%) were infected by Gram-negative bacteria. Acinetobacter lwoffii and Staphylococcus epidermidis were identified as the most common causes of sepsis among Gram-negative (30.7%) and Gram-positive (57.1%) bacteria, respectively Gram-negative bacteria exhibited the highest resistance to ceftriaxone (38.4%) and the highest susceptibility to imipenem (84.6%) in both laboratory and clinical settings. Gram-positive bacteria demonstrated the high susceptibility to vancomycin (78.5%), with only four patients exhibiting resistance to vancomycin in both laboratory and clinical settings. Encouragingly, there was a 77.5% concordance between laboratory and clinical antibiotic susceptibility testing results.
Conclusion: Based on these findings, vancomycin and imipenem are recommended as the preferred antibiotics for Gram-positive and Gram-negative bacteria, respectively. Given the high concordance (77.5%) between laboratory and clinical results, it is suggested to perform antibiogram test using E-test method on blood culture isolates in septicemia cases to guide appropriate antibiotic treatment.
Article Type: Original Research |
Subject:
Bacteriology
Received: 2023/12/18 | Accepted: 2024/06/25 | Published: 2024/08/20
Received: 2023/12/18 | Accepted: 2024/06/25 | Published: 2024/08/20
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