Volume 10, Issue 2 (2024)
IEM 2024, 10(2): 141-152 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Chandra Sekar P K, Veerabathiran R. A comprehensive investigation of the association between IL-6 rs1800795 (-147G/C) and severity of COVID-19: A meta-analysis of case-control studies. IEM 2024; 10 (2) :141-152
URL: http://iem.modares.ac.ir/article-4-74253-en.html
URL: http://iem.modares.ac.ir/article-4-74253-en.html
1- Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu 603103, India
2- Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu 603103, India ,rkgenes@gmail.com
2- Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu 603103, India ,
Abstract: (533 Views)
Background: To evaluate the relationship between COVID-19 and IL-6 polymorphism, a meta- analysis was conducted on seven studies, comprising 2265 controls and 1686 cases.
Materials & Methods: The literature on IL-6 polymorphism and its correlation with COVID-19 severity was extensively reviewed, covering research up to August 2023. Various databases including Google Scholar, PubMed, and Embase were utilized for literature search. Data analysis was performed using Cochrane Rob Tool 2 and Review Manager 5 software.
Findings: In this meta-analysis, none of the models showed a correlation between IL-6 polymorphism and COVID-19, including the allelic (G vs C, OR: 1.01, 95% CI: 0.63–1.64, p= .22, I2=91%), homozygote (GG vs. CC, OR: 1.08, 95% CI: 0.41–2.83, p= .87, I2=79%),
heterozygote (GC vs. CC, OR: 0.78, 95% CI: 0.34–1.78, p= .55, I2=73%), dominant (GG + GC vs CC, OR: 0.79, 95% CI: 0.32–1.95, p= .61, I2=81%), and recessive (OR: 1.26, 95% CI:
0.51–3.10, p= .61, I2=81%) models. Notably, funnel plot analysis revealed no indication of publication bias.
Conclusion: The findings of this meta-analysis indicated no significant correlation between IL-6 polymorphism and COVID-19 severity, suggesting insufficient data to establish a link between IL-6 (rs1800795) and more severe COVID-19 cases.
Materials & Methods: The literature on IL-6 polymorphism and its correlation with COVID-19 severity was extensively reviewed, covering research up to August 2023. Various databases including Google Scholar, PubMed, and Embase were utilized for literature search. Data analysis was performed using Cochrane Rob Tool 2 and Review Manager 5 software.
Findings: In this meta-analysis, none of the models showed a correlation between IL-6 polymorphism and COVID-19, including the allelic (G vs C, OR: 1.01, 95% CI: 0.63–1.64, p= .22, I2=91%), homozygote (GG vs. CC, OR: 1.08, 95% CI: 0.41–2.83, p= .87, I2=79%),
heterozygote (GC vs. CC, OR: 0.78, 95% CI: 0.34–1.78, p= .55, I2=73%), dominant (GG + GC vs CC, OR: 0.79, 95% CI: 0.32–1.95, p= .61, I2=81%), and recessive (OR: 1.26, 95% CI:
0.51–3.10, p= .61, I2=81%) models. Notably, funnel plot analysis revealed no indication of publication bias.
Conclusion: The findings of this meta-analysis indicated no significant correlation between IL-6 polymorphism and COVID-19 severity, suggesting insufficient data to establish a link between IL-6 (rs1800795) and more severe COVID-19 cases.
Article Type: Analytic Review |
Subject:
Virology
Received: 2024/03/12 | Accepted: 2024/05/27 | Published: 2024/06/21
Received: 2024/03/12 | Accepted: 2024/05/27 | Published: 2024/06/21
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |