Volume 10, Issue 4 (2024)
IEM 2024, 10(4): 0-0 |
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Abolnezhadian F, Yousefi Avarvand A, Makvandi M, Khosravi A D, Varnaseri M, Alavi S M, et al . Evaluation of Anti-inflammatory Effects of Naproxen on Pro-inflammatory Cytokines in COVID-19 Patients. IEM 2024; 10 (4)
URL: http://iem.modares.ac.ir/article-4-75376-en.html
URL: http://iem.modares.ac.ir/article-4-75376-en.html
Farhad Abolnezhadian1 
, Arshid Yousefi Avarvand * 2, Manoochehr Makvandi3 , Azar Dokht Khosravi , Mehran Varnaseri4 , Seyed Mohammad Alavi4 , Sara Iranparast5 , Gholamreza Shariati6
, Arshid Yousefi Avarvand * 2, Manoochehr Makvandi3 , Azar Dokht Khosravi , Mehran Varnaseri4 , Seyed Mohammad Alavi4 , Sara Iranparast5 , Gholamreza Shariati6
1- Department of Pediatrics, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,arshid.yousefi.avarvand@gmail.com
3- Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Department of Infectious, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6- Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
3- Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Department of Infectious, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6- Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract: (162 Views)
Background: COVID-19 (coronavirus disease 2019) was declared as a pandemic by the World Health Organization (WHO) in early 2020. The spectrum of clinical symptoms of COVID-19 patients, including asymptomatic and symptomatic cases, includes dry cough, fatigue, fever, shortness of breath, and gastrointestinal symptoms. However, increased immune inflammatory responses to stimuli could result in overproduction of pro-inflammatory cytokines, immunopathological complications, and death in patients with COVID-19. Given the anti-inflammatory effects of naproxen, this study aimed to evaluate the effect of naproxen on IL-1β, TNF-α, IL-6, IFN-γ, and TGF-β in COVID-19 patients.
Materials & Methods: Serum levels of IL-1β, TNF-α, IL-6, IFN-γ, and TGF-β were determined by a commercial ELISA (enzyme linked immunosorbent assay) kit before and after naproxen treatment.
Findings: According to the results, serum levels of IFN-γ and TGF-β cytokines significantly decreased in patients after treatment with naproxen. In addition, naproxen treatment was effective in reducing the serum levels of IL-6 and IL-1β in patients with COVID-19; however, it did not significantly change the serum level of TNF-α.
Conclusion: Overall, the findings demonstrated the effectiveness of naproxen on regulating the serum levels of pro-inflammatory cytokines in COVID-19 patients.
Materials & Methods: Serum levels of IL-1β, TNF-α, IL-6, IFN-γ, and TGF-β were determined by a commercial ELISA (enzyme linked immunosorbent assay) kit before and after naproxen treatment.
Findings: According to the results, serum levels of IFN-γ and TGF-β cytokines significantly decreased in patients after treatment with naproxen. In addition, naproxen treatment was effective in reducing the serum levels of IL-6 and IL-1β in patients with COVID-19; however, it did not significantly change the serum level of TNF-α.
Conclusion: Overall, the findings demonstrated the effectiveness of naproxen on regulating the serum levels of pro-inflammatory cytokines in COVID-19 patients.
Article Type: Original Research |
Subject:
Virology
Received: 2024/05/30 | Accepted: 2024/09/23 | Published: 2024/12/20
Received: 2024/05/30 | Accepted: 2024/09/23 | Published: 2024/12/20
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