Volume 4, Issue 4 (2018)                   IEM 2018, 4(4): 147-152 | Back to browse issues page

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Shariat Bahadori E, Sadraei J, Dalimi A. Evaluation of NT-ProBNP and Procalcitonin as Markers from Rodents with Myocardial Toxoplasmosis Using ECL Method: A Pilot Study. IEM. 2018; 4 (4) :147-152
URL: http://iem.modares.ac.ir/article-4-27073-en.html
1- Parasitology Department, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran
2- Parasitology Department, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran , sadraeij@modares.ac.ir
Abstract:   (4030 Views)
Aims: Toxoplasma parasites that extracted from different rodents are the same in immunologic and morphological characteristics but different in pathogenic characteristics. We found that the serum levels of ProBNP and Procalcitonin markers are high among these rodents. The aim of this study was the assessment of the serum levels of ProBNP and Procalcitonin markers among the rodents with myocardial .
Materials & Methods: In this study, we collected 286 rodents and extracted 250g of their heart tissues and blood samples to obtain DNA of T. . We detected the positive samples, using the nested PCR method. Then, we examined serum levels of Pro BNP and Procalcitonin markers, using Electro Chemo Luminescence method (ECL) for assessment of myocardial in this host. Data analysis was also conducted by the statistical analysis method. This study was performed from January to March 2017, based on the prevalence study.
Findings: In this study, 68/286 samples of rodents were positive for GRA6 gene and these positive samples had high levels of Pro BNP and Procalcitonin markers that indicated myocardial and acute inflammation among these animals.
Conclusion: In this study, we found that the GRA6 gene was very useful to follow up in the rodents of the Golestan province, northeast of Iran. Also, ProBNP and Procalcitonin markers were at high levels in myocardial .
Full-Text [PDF 749 kb]   (504 Downloads)    
Article Type: Original Research | Subject: Parasitology
Received: 2018/05/11 | Accepted: 2018/10/6 | Published: 2018/12/20

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