Volume 9, Issue 2 (2023)
IEM 2023, 9(2): 157-165 |
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Roshanravan M, Amini Z, Safdari M R, Kamel S, Javadzadeh S M, Namdar Ahmadabad H. Impact of Serum 25(OH) D Levels on Immune Responses to Hepatitis B Virus Vaccination in Healthy Adults: A Cross-Sectional Study in Mane and Samalghan City, Iran. IEM 2023; 9 (2) :157-165
URL: http://iem.modares.ac.ir/article-4-67478-en.html
URL: http://iem.modares.ac.ir/article-4-67478-en.html
Mostafa Roshanravan1 
, Zakiyeh Amini1 , Mohammad Reza Safdari2 , Sahar Kamel3 , Seyed Mohammad Javadzadeh4 , Hasan Namdar Ahmadabad * 5
, Zakiyeh Amini1 , Mohammad Reza Safdari2 , Sahar Kamel3 , Seyed Mohammad Javadzadeh4 , Hasan Namdar Ahmadabad * 5
1- Department of Nursing, Faculty of Nursing, North Khorasan University of Medical Sciences, Bojnurd, Iran
2- Department of Orthopedic Surgery, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
4- Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5- Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. ,h.namdar@nkumms.ac.ir
2- Department of Orthopedic Surgery, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
4- Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5- Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. ,
Abstract: (802 Views)
Backgrounds: Several studies have elucidated vitamin D as an important immunomodulatory factor regulating immune responses to different viral infections and vaccines. This study aimed to evaluate the impact of 25(OH) D serum levels on immune responses to hepatitis B virus (HBV) vaccine.
Materials & Methods: This study was conducted on 134 healthy individuals aged 18-35 years, referring to health centers for HBV vaccination in Mane and Samalghan city in North Khorasan, Iran from June to September 2021. Demographic data were collected through a questionnaire. Serum 25(OH) D levels were analyzed using commercial sandwich ELISA kits. Anti-hepatitis B surface antibody (anti-HBsAb) levels were determined in blood samples 4-6 weeks post-vaccination.
Findings: The prevalence of vitamin D deficiency and insufficiency among the participants was 46.3 was 34.3%, respectively. The level of 25(OH) D was insignificantly higher in women than in men. There was no significant association between serum 25(OH) D levels and participants' ethnicities and BMI ranges. Anti-HBsAb titer was significantly higher in participants with sufficient vitamin D levels compared to those with insufficient and deficient levels (1835 ± 252.55 vs. 1129 ± 120.7 and 1363 ± 0.125 ng/ml). Serum anti-HBsAb levels post HBV vaccination were significantly higher in women and younger individuals than in men and older individuals, respectively.
Conclusion: This study findings suggest that participants with different serum vitamin D levels produce seroprotective antibody titers post HBV vaccination, while those with sufficient vitamin D levels may produce higher titers against HBV vaccine.
Materials & Methods: This study was conducted on 134 healthy individuals aged 18-35 years, referring to health centers for HBV vaccination in Mane and Samalghan city in North Khorasan, Iran from June to September 2021. Demographic data were collected through a questionnaire. Serum 25(OH) D levels were analyzed using commercial sandwich ELISA kits. Anti-hepatitis B surface antibody (anti-HBsAb) levels were determined in blood samples 4-6 weeks post-vaccination.
Findings: The prevalence of vitamin D deficiency and insufficiency among the participants was 46.3 was 34.3%, respectively. The level of 25(OH) D was insignificantly higher in women than in men. There was no significant association between serum 25(OH) D levels and participants' ethnicities and BMI ranges. Anti-HBsAb titer was significantly higher in participants with sufficient vitamin D levels compared to those with insufficient and deficient levels (1835 ± 252.55 vs. 1129 ± 120.7 and 1363 ± 0.125 ng/ml). Serum anti-HBsAb levels post HBV vaccination were significantly higher in women and younger individuals than in men and older individuals, respectively.
Conclusion: This study findings suggest that participants with different serum vitamin D levels produce seroprotective antibody titers post HBV vaccination, while those with sufficient vitamin D levels may produce higher titers against HBV vaccine.
Article Type: Original Research |
Subject:
Virology
Received: 2023/02/12 | Accepted: 2023/06/3 | Published: 2023/08/19
Received: 2023/02/12 | Accepted: 2023/06/3 | Published: 2023/08/19
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